MAN2B2 Antibodies, cDNA Clones Research Reagents

MAN2B2 (Mannosidase Alpha Class 2B Member 2), located on 4p16.1, is a Protein Coding gene. The encoded protein is a core-specific mannosidase that cleaves the alpha-1,6 mannose linkage of the N-glycan core structure following cleavage of a GlcNAc residue from the reducing terminus by di-N-acetylchitobiase. It belongs to the glycosyl hydrolase 38 family. The expression of the MAN2B2 homolog can serve as a good marker for the late stages of type A spermatogonia and may have an important role to play in the early step of spermatogenesis in mice.

MAN2B2 Antibody (1)

    MAN2B2 cDNA Clone (14)

    NM_001292038.1

    In expression vector

    NM_008550.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MAN2B2 の背景知識

    The expression of the MAN2B2 homolog can serve as a good marker for the late stages of type A spermatogonia and may have an important role to play in the early step of spermatogenesis in mice. Two structurally-related members of the lysosomal mannosidase family, the broad substrate specificity enzyme human lysosomal alpha-mannosidase (hLM, MAN2B1) and the human core alpha-1, 6-specific mannosidase (hEpman, MAN2B2) act in a complementary fashion on different glycosidic linkages, to effect glycan degradation in the lysosome. At least two kinds of alpha-D-mannosidase (lysosomal type enzyme and 135 kDa alpha-D-mannosidase (MAN2B2)) were contained in the porcine epididymal fluid. The activity of the lysosomal type enzyme is much higher than MAN2B2 at the physiological pH. circRNA MAN2B2 (circMAN2B2) acted as an Onco-miRNA in hepatocellular carcinoma (HCC) by sponging miRNA-217 to promote MAPK1 expression.

    MAN2B2 の参考文献

    • Venkatesan M, et al. (2009) Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties. Protein Sci 18 (11): 2242-2251.
    • Jin YZ, et al. (1999) Purification and properties of major alpha-d-mannosidase in the luminal fluid of porcine epididymis. Biochim Biophys Acta 1432 (2): 382-392.
    • Hiramoto S, et al. (1997) Stage-specific expression of a mouse homologue of the porcine 135kda alpha-d-mannosidase (man2b2) in type a spermatogonia. Biochem Biophys Res Commun 241 (2): 439-445.
    • Fu X, et al. (2020) Circular rna man2b2 promotes cell proliferation of hepatocellular carcinoma cells via the mirna-217/mapk1 axis. J Cancer 11 (11): 3318-3326.

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