MAGOH Proteins, Antibodies, cDNA Clones Research Reagents

MAGOH (Mago Homolog, Exon Junction Complex Subunit, also known as MAGOH1; MAGOHA), located on 1p32.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 17164 Da protein composed of 146 amino acids. Drosophila that has mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. Diseases such as Metaphyseal Chondrodysplasia, Schmid Type, and Primary Autosomal Recessive Microcephaly are associated with MAGOH. The related pathways of MAGOH include Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm.

MAGOH Protein (1)

    MAGOH Antibody (2)

      MAGOH cDNA Clone (15)


      クローニングベクター cDNA 製品

      In lentiviral vector

      MAGOH qPCR Primer (1)

      MAGOH の背景知識

      MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. MAGOH is the human homolog of Drosophila mago nashi, a protein that is required for normal germplasm development in the Drosophila embryo. In mammals, mRNA expression is not limited to the germplasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. The exon junction complex (EJCs) are deposited on messenger RNAs (mRNAs) during splicing and their core consists of eIF4A3, MLN51, Y14, and MAGOH. Both MAGOH proteins interact with other EJC components, incorporate into mRNA-bound EJCs, and activate nonsense-mediated decay. Diseases associated with MAGOH include Metaphyseal Chondrodysplasia, Schmid Type, and Primary Autosomal Recessive Microcephaly.

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