MAGEA10 Antibodies, cDNA Clones Research Reagents

MAGEA10 (MAGE Family Member A10, also known as CT1.10; MAGE10), located on Xq28, is a Protein Coding gene. This gene is a member of the MAGE-A family of genes that are active in various types of tumors. The members of this family encode proteins with 50 to 80% sequence identity to each other. MAGEA10 appeared to be a weakly expressed member of the family. MAGEA10 is a nuclear protein, which is often highly expressed in lung, skin, and urothelial tumor cells. It represents an attractive target for cancer immunotherapy.

MAGEA10 Antibody (1)

    MAGEA10 cDNA Clone (15)

    BC004105

    クローニングベクター cDNA 製品

    In lentiviral vector

    MAGEA10 qPCR Primer (1)

    MAGEA10 の背景知識

    MAGE-A10 is a member of the MAGE protein family (melanoma-associated antigen) which is overexpressed in cancer cells. MAGE-A10 exerts its effects at the level of the epithelial-mesenchymal transition (EMT) presumably by regulating the expression of adhesion molecules. MAGEA10, a testis antigen expressed in tumors but not in normal tissues except for the testis and placenta, represents an attractive target for cancer immunotherapy. However, suppressive cytoenvironment and requirement of specific HLA-alleles presentation frequently led to immunotherapy failure. Melanoma-associated antigen A (MAGEA) represent a class of tumor antigens that are expressed in a variety of malignant tumors. The restricted expression and immunogenicity of these antigens make them ideal targets for immunotherapy in human cancer.

    MAGEA10 の参考文献

    • Wang L, et al. (2015) Magea10 gene expression in non-small cell lung cancer and a549 cells, and the affinity of epitopes with the complex of hla-a(∗)0201 alleles. Cell Immunol 297 (1): 10-18.
    • Õunap K, et al. (2018) Antibody response against cancer-testis antigens magea4 and magea10 in patients with melanoma. Oncol Lett 16 (1): 211-218.
    • Mendonça BDS, et al. (2017) Suppression of mage-a10 alters the metastatic phenotype of tongue squamous cell carcinoma cells. Biochem Biophys Rep 10 267-275.

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