MAG Proteins, Antibodies, cDNA Clones Research Reagents

MAG (Myelin Associated Glycoprotein, also known as GMA; S-MAG; SPG75; SIGLEC4A; SIGLEC-4A), located on 19q13.12, is conserved in Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 69069 Da protein composed of 626 amino acids. The protein encoded by this gene is a type I membrane protein and a member of the immunoglobulin superfamily. Diseases such as Spastic Paraplegia 75, Autosomal Recessive, and Polyneuropathy are associated with MAG. The related pathways of MAG include Neuroscience and Guidance Cues and Growth Cone Motility.

MAG Protein (4)

    MAG Antibody (2)

      MAG cDNA Clone (14)

      NM_001199216.1

      In expression vector

      NM_010758.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      MAG qPCR Primer (1)

      MAG Lysate (4)

        MAG の背景知識

        The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of Periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance, and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintenance of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dorsal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influence both temporally and spatially regeneration in the PNS.

        MAG の参考文献

        • Quarles RH. (2007) Myelin-associated glycoprotein (MAG): past, present and beyond. J Neurochem. 100(6):1431-48.
        • Mukhopadhyay G, et al. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13(3): 757-67.
        • Barton DE, et al. (1987) The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. Genomics. 1(2): 107-12.

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