LYVE1 Proteins, Antibodies, cDNA Clones Research Reagents

LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1, also known as HAR; XLKD1; LYVE-1; CRSBP-1), located on 11p15.4, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 35213 Da protein composed of 322 amino acids. This gene encodes a type I integral membrane glycoprotein. Diseases such as Intramuscular Hemangioma and Middle Cerebral Artery Infarction are associated with LYVE1. The related pathways of LYVE1 include Cell adhesion_Cell-matrix glycoconjugates and Glycosaminoglycan metabolism.

LYVE1 Protein (1)

    LYVE1 Antibody (1)

      LYVE1 cDNA Clone (26)

      NM_006691.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_053247.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      LYVE1 Lysate (1)

        LYVE1 の背景知識

        LYVE1, also known as LYVE-1, is a type I integral membrane glycoprotein. It contains 1 Link domain and is mainly expressed in endothelial cells lining lymphatic vessels. LYVE1 acts as a receptor and binds to both soluble and immobilized hyaluronan. It may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE1 also is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. It also functions as a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding. It may act as a hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

        LYVE1 の参考文献

        • Jackson DG. (2003) The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med. 13(1):1-7.
        • Banerji S, et al. (1999) LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol. 144(4):789-801.
        • Mouta Carreira C, et al. (2001) LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 61(22): 8079-84.
        • Cursiefen C, et al. (2002) Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci. 43(7):2127-35.

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