Lumican Proteins, Antibodies, cDNA Clones Research Reagents

LUM (Lumican, also known as LDC; SLRR2D), located on 12q21.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 38429 Da protein composed of 338 amino acids. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Diseases such as Cornea Plana and Macular Dystrophy, Corneal are associated with LUM. The related pathways of LUM include Degradation of the extracellular matrix and Keratan sulfate/keratin metabolism.

Lumican Protein (1)

    Lumican Antibody (5)

      Lumican cDNA Clone (28)

      NM_002345.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008524.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_031050.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Lumican qPCR Primer (1)

      Lumican Lysate (1)

        Lumican の背景知識

        Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major component of the cornea, dermal, and muscle connective tissues. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration, and tissue repair. lumican expressed in injured epithelium may modulate cell behavior such as adhesion or migration, thus contributing to corneal epithelial wound healing. Lumican plays a crucial role in the regulation of collagen assembly into fibrils in various connective tissues and serve as a definitive link between a necessity for lumican in the development of a highly organized collagenous matrix and corneal transparency.

        Lumican の参考文献

        • Saika S, et al. (2000) Role of lumican in the corneal epithelium during wound healing. J Biol Chem. 275(4): 2607-12.
        • Chakravarti S, et al. (1998) Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol. 141(5): 1277-86.
        • Ezura Y, et al. (2000) Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. J Cell Biol. 151(4): 779-88.

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