LSM14A Antibodies, cDNA Clones Research Reagents

LSM14A (LSM14A MRNA Processing Body Assembly Factor, also known as RAP55; FAM61A; RAP55A; C19orf13), located on 19q13.11, is a Protein Coding gene. The gene encodes a 463-amino acid protein with a predicted molecular mass of 50.5 kD that contains an N-terminal LSM domain and 2 RGG-rich domains flanking an FDF motif at the C terminus. It belongs to the LSM14 family. Human LSm14A is a key component of the processing body (P-body) assembly that mediates interferon-β (IFN-β) production by sensing viral RNA or DNA.

LSM14A Antibody (1)

    LSM14A cDNA Clone (17)

    BC016842

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_006228858.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    LSM14A qPCR Primer (1)

    LSM14A の背景知識

    Human LSm14A has recently been found as a processing body-associated sensor of intracellular viral nucleic acids and triggers signaling for type I IFN expression. Human LSm14A is a key component of the processing body (P-body) assembly that mediates interferon-β (IFN-β) production by sensing viral RNA or DNA. LSm14A, a member of the LSM family involved in RNA processing in the processing bodies, binds to synthetic or viral RNA and DNA and mediates IRF3 activation and IFN-β induction. LSm14A is a key innate immunity component of the processing body (P-body) that mediates interferon-β (IFN-β) signaling by viral RNA. Knockdown of LSm14A inhibits cytosolic RNA- and DNA-trigger type I IFN production and cellular antiviral response. Moreover, LSm14A is essential for early-phase induction of IFN-β after either RNA or DNA virus infection. chicken LSm14A (cLSm14A) is an important sensor that mediates innate immunity in the chicken against NDV infections.

    LSM14A の参考文献

    • Wen G, et al. (2013) Functional characterization of porcine lsm14a in ifn-β induction. Vet Immunol Immunopathol 155 (1-2): 110-116.
    • Tian L, et al. (2019) Transcriptional responses of lsm14a after infection of blue eggshell layers with newcastle disease viruses. J Vet Med Sci 81 (10): 1468-1474.
    • Li Y, et al. (2012) Lsm14a is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A 109 (29): 11770-11775.
    • Hua K, et al. (2017) Functional characterization of duck lsm14a in ifn-β induction. Dev Comp Immunol 76 255-261.

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