LSAMP Proteins, cDNA Clones Research Reagents

LSAMP (Limbic System Associated Membrane Protein, also known as LAMP; IGLON3), located on 3q13.31, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces a 37393 Da protein composed of 338 amino acids. This gene encodes a member of the immunoglobulin LAMP, OBCAM, and neurotrimin (IgLON) family of proteins. Diseases such as Ring Dermoid Of Cornea are associated with LSAMP. The related pathways of LSAMP include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

LSAMP Protein (2)

    LSAMP cDNA Clone (13)


    クローニングベクター cDNA 製品

    In lentiviral vector

    LSAMP qPCR Primer (1)

    LSAMP Lysate (2)

      LSAMP の背景知識

      The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning, and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there has been found that rats with an increased level of anxiety had 1.6-fold higher expression of the LsAMP gene in the periaqueductal gray compared to rats with a low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.

      LSAMP の参考文献

      • Zacco A. et al., 1990, The Journal of Neuroscience. 10(1): 73-90.
      • Pimenta AF. et al., 1996, Gene. 170(2) :189-95.

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