LRRN3 Proteins, Antibodies, cDNA Clones Research Reagents

LRRN3 (Leucine-Rich Repeat Neuronal 3, also known as NLRR3; NLRR-3; FIGLER5), located on 7q31.1, is a Protein Coding gene. The gene produces a 79424 Da protein composed of 708 amino acids. LRRN3 is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. LRRN3 plays an important role in cerebellum postnatal development. LRRN3 may be an important component of the pathophysiological response to brain injury. Diseases such as Vascular Skin Disease and Autism Spectrum Disorder are associated with LRRN3.

LRRN3 Protein (1)

    LRRN3 Antibody (2)

      LRRN3 cDNA Clone (14)

      BC035133.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001099658.1

      In expression vector

      LRRN3 qPCR Primer (1)

      LRRN3 Lysate (1)

        LRRN3 の背景知識

        Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. Leucine-rich repeats are short sequence motifs present in some proteins with diverse functions and cellular locations. All proteins containing these repeats are thought to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor protein has revealed that leucine-rich repeats correspond to β-α structural units. These units are arranged so that they form a parallel β-sheet with one surface exposed to solvent so that the protein acquires an unusual, non-globular shape. These two features may be responsible for the protein-binding functions of proteins containing leucine-rich repeats. LRRN3 plays an important role in cerebellum postnatal development. In a unilateral cortical injury cerebral cortex, NLRR-3 mRNA increased in layers 2-3 which suggests that NLRR-3 may be an important component of the pathophysiological response to brain injury.

        LRRN3 の参考文献

        • Yang J, et al. (2011) Role of LRRN3 in the cerebellum postnatal development in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 36 (5): 424-9.
        • Hutcheson HB, et al. (2004) Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. BMC Med Genet. 5: 12.
        • Ishii N, et al. (1996) Increased expression of NLRR-3 mRNA after cortical brain injury in mouse. Brain Res Mol Brain Res. 40 (1): 148-52.

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