LRRC3B Proteins, Antibodies, cDNA Clones Research Reagents

LRRC3B (Leucine-Rich Repeat Containing 3B, also known as LRP15), located on 3p24.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 29275 Da protein composed of 259 amino acids. The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. LRRC3B confers resistance to ultraviolet (UV) damage and accelerates DNA repair rate in cells. LRRC3B could be a new target for lung cancer therapy.

LRRC3B Protein (2)

    LRRC3B Antibody (2)

      LRRC3B cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      LRRC3B qPCR Primer (1)

      LRRC3B Lysate (2)

        LRRC3B の背景知識

        LRRC3B expression is downregulated in many kinds of malignant tumors and it is regarded as a tumor inhibition protein. The leucine-rich repeat-containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukemias.LRRC3B expression is downregulated in lung cancer cell lines and LRRC3B could inhibit lung cancer cell proliferation, invasion, and cell cycle progress. LRRC3B could be a new target for lung cancer therapy.LRRC3B depletion in HBE cells promoted proliferation and invasion,suggesting that LRRC3B may serve as an important tumor suppressor in NSCLC.

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