LRP10 Proteins, Antibodies, cDNA Clones Research Reagents

All LRP10 reagents are produced in house and quality controlled, including 1 LRP10 Antibody, 13 LRP10 Gene, 2 LRP10 Lysate, 2 LRP10 Protein. All LRP10 reagents are ready to use.

LRP10 Protein (2)

    LRP10 Antibody (1)

      LRP10 cDNA Clone (13)

      NM_014045.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      LRP10 Lysate (2)

        LRP10 の背景知識

        Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN), plasma membrane (PM), and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing, suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.

        LRP10 の参考文献

        • Jeong YH, et al. (2010) The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 392(4): 495-9.
        • Beisiegel U, et al. (1991) Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A. 88(19): 8342-6.
        • Strickland DK, et al. (1990) Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265(29): 17401-4.

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