LRP10 Proteins, Antibodies, cDNA Clones Research Reagents

All LRP10 reagents are produced in house and quality controlled, including 1 LRP10 Antibody, 13 LRP10 Gene, 2 LRP10 Lysate, 2 LRP10 Protein. All LRP10 reagents are ready to use.

LRP10 Protein (2)

    LRP10 Antibody (1)

      LRP10 cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      LRP10 Lysate (2)

        LRP10 の背景知識

        Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN), plasma membrane (PM), and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing, suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.

        LRP10 の参考文献

        • Jeong YH, et al. (2010) The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 392(4): 495-9.
        • Beisiegel U, et al. (1991) Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A. 88(19): 8342-6.
        • Strickland DK, et al. (1990) Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265(29): 17401-4.

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