LRIG2 Antibodies, cDNA Clones Research Reagents

LRIG2 (Leucine-Rich Repeats And Immunoglobulin Like Domains 2, also known as LIG2; UFS2; LIG-2), located on 1p13.2, is a Protein Coding gene. This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signaling, resulting in increased proliferation. The LRIG2 protein was predicted to have the same domain organization as LRIG1 with a signal peptide, an extracellular part containing15 leucine-rich repeats, and three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail.

LRIG2 Antibody (1)

    LRIG2 cDNA Clone (13)

    NM_014813.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    LRIG2 の背景知識

    The LRIG2 gene was localized to chromosome 1p13 and had an open reading frame of 1065 amino acids. The LRIG2 protein was predicted to have the same domain organization as LRIG1 with a signal peptide, an extracellular part containing15 leucine-rich repeats, and three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. The LRIG2 amino acid sequence was 47% identical to human LRIG1 and mouse Lrig1 (also known as Lig-1). Leucine-rich repeat and immunoglobulin-like domain 2 (LRIG2) is an evolutionarily conserved gene. LRIG2 is a growth suppressor of endometrial adenocarcinoma cells. LRIG2 is a transmembrane protein involved in feedback loop regulation of the ERBB receptor family during NMSC. LRIG2 was identified to be up-regulated in various types of squamous cell carcinoma (SCC), but little is known about LRIG2 in cutaneous SCC (cSCC).

    LRIG2 の参考文献

    • Xiao Q, et al. (2019) [corrigendum] lrig2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing pdgfrβ signaling. Int J Oncol 54 (6): 2257.
    • Suh DS, et al. (2018) Lrig2 is a growth suppressor of hec-1a and ishikawa endometrial adenocarcinoma cells by regulating pi3k/akt- and egfr-mediated apoptosis and cell-cycle. Oncogenesis 7 (1): 3.
    • Holmlund C, et al. (2004) Characterization and tissue-specific expression of human lrig2. Gene 332 35-43.
    • Hoesl C, et al. (2019) The transmembrane protein lrig2 increases tumor progression in skin carcinogenesis. Mol Oncol 13 (11): 2476-2492.

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