LPAL2 Proteins, cDNA Clones Research Reagents

LPAL2 (Lipoprotein(A) Like 2, Pseudogene, also known as APOA2; APOAL; APOARGC; apo(a)rg-C), located on 6q25.3, is a Pseudogene. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame. The gene produces a 14886 Da protein composed of 132 amino acids. The protein contains an N-terminal secretion signal followed by a single kringle domain. LPAL2 is C-terminally truncated compared with apolipoprotein(a) (LPA), and its kringle domain shares 72% identity with the first kringle domain of LPA.

LPAL2 Protein (1)

    LPAL2 cDNA Clone (13)

    BC110570

    クローニングベクター cDNA 製品

    In lentiviral vector

    LPAL2 qPCR Primer (1)

    LPAL2 Lysate (1)

      LPAL2 の背景知識

      LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a)-like 2 (LPAL2), and the lipoprotein (a) (LPA) gene cluster, which encodes apolipoprotein (a) [apo (a)] of the lipoprotein (a) [Lp (a)] lipoprotein particle, have been suggested to contribute to the risk of coronary artery disease (CAD). Recent genome-wide association studies have identified that genetic variants in the SLC22A3-LPAL2-LPA gene cluster influence plasma lipoprotein(a) [Lp(a)] concentration.

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