LOXL2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LOXL2 (Lysyl Oxidase Like 2, also known as LOR; LOR2; WS9-14), located on 8p21.3, is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces an 86725 Da protein composed of 774 amino acids. This gene encodes a member of the lysyl oxidase gene family. Diseases such as Hyperostosis Cranialis Interna and Mid-Dermal Elastolysis are associated with LOXL2. The related pathways of LOXL2 include Degradation of the extracellular matrix and Collagen chain trimerization.

LOXL2 Protein (3)

    LOXL2 Antibody (3)

      LOXL2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      LOXL2 cDNA Clone (13)

      NM_002318.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      LOXL2 qPCR Primer (1)

      LOXL2 Lysate (3)

        LOXL2 の背景知識

        Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.

        LOXL2 の参考文献

        • Peng,L. et al., 2009, Carcinogenesis. 30 (10):1660-9.
        • Hollosi,P. et al., 2009, Int J Cancer. 125 (2):318-27.
        • Rückert,F. et al., 2010, Int J Colorectal Dis. 25 (3):303-11.
        • Iftikhar,M. et al., 2011, J Biol Chem. 286 (2):909-18.

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