LOX-1 Proteins, Antibodies, cDNA Clones Research Reagents

OLR1 (Oxidized Low-Density Lipoprotein Receptor 1, also known as LOX1; LOXIN; SLOX1; CLEC8A; SCARE1), located on 12p13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 30959 Da protein composed of 273 amino acids. This gene encodes a low-density lipoprotein receptor that belongs to the C-type lectin superfamily. Diseases such as Myocardial Infarction and Atherosclerosis Susceptibility are associated with OLR1. The related pathways of OLR1 include Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.

LOX-1 Protein (4)

    LOX-1 Antibody (9)

      LOX-1 cDNA Clone (39)

      NM_002543.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_133306.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001194668.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      LOX-1 qPCR Primer (2)

      LOX-1 Lysate (4)

        LOX-1 の背景知識

        Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is induced by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes, and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions.

        LOX-1 の参考文献

        • Hinagata J, et al. (2006) Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res. 69 (1): 263-71.
        • Melan MA, et al. (1994) The LOX1 Gene of Arabidopsis Is Temporally and Spatially Regulated in Germinating Seedlings. Plant Physiol. 105 (1): 385-93.
        • Saito A, et al. (2010) Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque. Acta Neurochir (Wien). 152 (4): 589-95.

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