LITAF cDNA Clones Research Reagents

LITAF (Lipopolysaccharide-Induced TNF Factor, also known as PIG7; SIMPLE; TP53I7), located on 16p13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 17107 Da protein composed of 161 amino acids. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. Diseases such as Charcot-Marie-Tooth Disease, Demyelinating, Type 1C, and Charcot-Marie-Tooth Disease are associated with LITAF. The related pathways of LITAF include Lysosome and NF-kappaB Signaling.

LITAF cDNA Clone (28)

BC101401

クローニングベクター cDNA 製品

In lentiviral vector

NM_019980.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_001105735.2

クローニングベクター cDNA 製品

In lentiviral vector

LITAF qPCR Primer (1)

LITAF の背景知識

LITAF (Lipopolysaccharide-Induced TNF Factor) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes the lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. It belongs to the CDIP1/LITAF family. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Several mutations in LITAF cause autosomal-dominant Charcot Marie Tooth disease type 1C. These mutations map to a highly conserved C-terminal region termed the LITAF domain, which includes a 22 residue hydrophobic sequence and flanking cysteine-rich regions that contain peptide motifs found in zinc fingers.

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