Lipocalin-2/LCN2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Lipocalin-2/LCN2 reagents are produced in house and quality controlled, including 15 Lipocalin-2/LCN2 Antibody, 1 Lipocalin-2/LCN2 ELISA, 39 Lipocalin-2/LCN2 Gene, 4 Lipocalin-2/LCN2 Lysate, 4 Lipocalin-2/LCN2 Protein, 3 Lipocalin-2/LCN2 qPCR. All Lipocalin-2/LCN2 reagents are ready to use.

Lipocalin-2/LCN2 Protein (4)

    Lipocalin-2/LCN2 Antibody (15)

      Lipocalin-2/LCN2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      Lipocalin-2/LCN2 cDNA Clone (39)

      NM_005564.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008491.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_130741.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Lipocalin-2/LCN2 Lysate (4)

        Lipocalin-2/LCN2 の背景知識

        Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

        Lipocalin-2/LCN2 の参考文献

        • Schmidt-Ott KM, et al. (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens. 15(4): 442-9.
        • Bolignano D, et al. (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288(1): 10-6.
        • Soni SS, et al. (2010) NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 42(1): 141-50.
        • Bolignano D, et al. (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest. 40(3): 273-6.

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