LIN28A Antibodies, cDNA Clones Research Reagents

LIN28A (Lin-28 Homolog A, also known as CSDD1; LIN28; ZCCHC1; lin-28A), located on 1p36.11, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 22743 Da protein composed of 209 amino acids. This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. Diseases such as Atypical Teratoid Rhabdoid Tumor and Central Nervous System Primitive Neuroectodermal Neoplasm are associated with LIN28A. The related pathways of LIN28A include Transcriptional regulation of pluripotent stem cells and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

LIN28A Antibody (1)

    LIN28A cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    LIN28A qPCR Primer (1)

    LIN28A の背景知識

    LIN28A (Lin-28 Homolog A) is a Protein Coding gene. LIN28A, a highly-conserved RNA binding protein expressed during embryogenesis, plays roles in development, pluripotency, metabolism, as well as tissue repair in adults. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. LIN28 plays a critical role in the developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress the maturation of let-7 microRNAs and enhance the translation of certain mRNAs. Aberrant expression of this gene is associated with cancer progression in multiple tissues. LIN28A is an important factor in tumor cells and ESCs, it is an inhibitor of the intracellular endoplasmic reticulum (ER)related protein translation in ESCs.

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