LILRB3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LILRB3 (Leukocyte Immunoglobulin Like Receptor B3, also known as HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6), located on 19q13.42, is conserved in chimpanzee, dog, mouse, and rat. The gene produces a 69386 Da protein composed of 631 amino acids. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. Diseases such as Takayasu Arteritis and Bare Lymphocyte Syndrome, Type I are associated with LILRB3. The related pathways of LILRB3 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

LILRB3 Protein (4)

    LILRB3 Antibody (12)

      LILRB3 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      LILRB3 cDNA Clone (13)

      BC112198.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      LILRB3 Lysate (3)

        LILRB3 の背景知識

        Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3 / CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3 / CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3 / CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.

        LILRB3 の参考文献

        • Huang,J. et al., 2010, J Virol. 84 (18): 9463-71.
        • Arm J.P. et al., 1997, J. Immunol. 159:2342-2349.
        • Wende H. et al., 2000, Immunogenetics 51:703-713.
        • Yu L.-R. et al., 2007,J. Proteome Res. 6:4150-4162.

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