LFA-1 Antibodies, cDNA Clones Research Reagents

ITGAL (Integrin Subunit Alpha L, also known as CD11A; LFA-1; LFA1A), located on 16p11.2, is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The gene produces a 128770 Da protein composed of 1170 amino acids. ITGAL encodes the integrin alpha L chain. The ITGAL protein shares 36% identity with the alpha subunits of MAC1 (ITGAM) and p150,95 (ITGAX). Diseases such as Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency are associated with ITGAL. The related pathways of ITGAL include the Integrin Pathway and Degradation of the extracellular matrix.

LFA-1 Antibody (2)

    LFA-1 cDNA Clone (26)

    NM_002209.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001033998.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    LFA-1 qPCR Primer (2)

    LFA-1 の背景知識

    ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. ITGAL encodes the integrin alpha L chain, which belongs to the integrin alpha chain family. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. Hypomethylation of regions flanking the ITGAL promoter may increase CD11a expression and suggest that age-dependent hypomethylation of promoters lacking CpG islands, perhaps due to decreased DNA methyltransferase expression, may be one mechanism contributing to increased T cell gene expression with aging. Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency.

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