LCAT Proteins, Antibodies, cDNA Clones Research Reagents

LCAT (Lecithin-Cholesterol Acyltransferase), located on 16q22.1, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 49578 Da protein composed of 440 amino acids. This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. Diseases such as Lecithin: Cholesterol Acyltransferase Deficiency and Fish-Eye Disease are associated with LCAT. The related pathways of LCAT include Lipoprotein metabolism and Statin Pathway.

LCAT Protein (1)

    LCAT Antibody (1)

      LCAT cDNA Clone (28)

      BC014781

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008490.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_017024.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      LCAT qPCR Primer (1)

      LCAT Lysate (1)

        LCAT の背景知識

        Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation and is a key component of the reverse cholesterol transport (RCT) pathway which removes excess cholesterol molecules from the peripheral tissues to the liver for excretion. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship with high-sensitivity C-reactive protein (hsCRP).

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