LBP Proteins, Antibodies, cDNA Clones Research Reagents

LBP (Lipopolysaccharide Binding Protein, also known as BPIFD2), located on 20q11.23, is conserved in Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 53384 Da protein composed of 481 amino acids. The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. LBP and another acute-phase reactant, bactericidal permeability-increasing protein (BPI), bind LPS with high affinity. Diseases such as Toxic Pneumonitis and Alcoholic Hepatitis are associated with LBP. The related pathways of LBP include Activated TLR4 signaling and Tuberculosis.

LBP Protein (1)

    LBP Antibody (1)

      LBP cDNA Clone (13)

      NM_004139.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      LBP qPCR Primer (1)

      LBP Lysate (1)

        LBP の背景知識

        Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and purified aggregates of extracted endotoxin and catalyzes the delivery of endotoxin to the membrane ( mCD14, GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to endotoxin. LBP efficiently catalyzes the transfer of individual molecules of endotoxin to (s)CD14 only when LBP–endotoxin aggregates are formed in the presence of albumin. In the presence of EDTA, LBP binding promotes further disaggregation of endotoxin. LBP binding does not have such drastic effects under more physiological conditions, but may still induce more subtle topological rearrangements of endotoxin.

        LBP の参考文献

        • J. Weiss, 2003, Biochemical Society Transactions: Volume 31, part 4: 785-790.
        • RR Schumann, et al., Science, 1990, Vol 249, Issue 4975: 1429-143.
        • Carsten J. Kirschning, et al., 1997, Genomics, Volume 46, Issue 3: 416-25.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.