Latexin Proteins, Antibodies, cDNA Clones Research Reagents

All Latexin reagents are produced in house and quality controlled, including 12 Latexin Antibody, 30 Latexin Gene, 5 Latexin IP Kit, 1 Latexin Lysate, 3 Latexin Protein, 2 Latexin qPCR. All Latexin reagents are ready to use.

Latexin Protein (3)

    Latexin Antibody (12)

      Latexin cDNA Clone (30)

      NM_020169.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_016753.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      Latexin Lysate (1)

        Latexin の背景知識

        Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to theprotease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

        Latexin の参考文献

        • Liu Q., et al.,(2000), Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. Mol. Biol. Rep. 27:241-246.
        • Gauci S., et al., (2009), Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.nal. Chem. 81:4493-4501.
        • Muzny D.M., et al.,(2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.

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