LAMP3/CD208 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All LAMP3/CD208 reagents are produced in house and quality controlled, including 8 LAMP3/CD208 Antibody, 1 LAMP3/CD208 ELISA, 39 LAMP3/CD208 Gene, 2 LAMP3/CD208 Lysate, 2 LAMP3/CD208 Protein, 2 LAMP3/CD208 qPCR. All LAMP3/CD208 reagents are ready to use.

LAMP3/CD208 Protein (2)

    LAMP3/CD208 Antibody (8)

      LAMP3/CD208 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      LAMP3/CD208 cDNA Clone (39)

      NM_014398.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_177356.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001032872.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      LAMP3/CD208 Lysate (2)

        LAMP3/CD208 の背景知識

        Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD28, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm18, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

        LAMP3/CD208 の参考文献

        • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
        • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
        • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.

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