LAIR1 Proteins, Antibodies, cDNA Clones Research Reagents

All LAIR1 reagents are produced in house and quality controlled, including 5 LAIR1 Antibody, 26 LAIR1 Gene, 4 LAIR1 Lysate, 6 LAIR1 Protein, 3 LAIR1 qPCR. All LAIR1 reagents are ready to use.

LAIR1 Protein (6)

    LAIR1 Antibody (5)

      LAIR1 cDNA Clone (26)

      BC027899

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001029928.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      LAIR1 Lysate (4)

        LAIR1 の背景知識

        Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.

        LAIR1 の参考文献

        • Meyaard L, et al. (1999) Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 162 (10): 5800-4.
        • Meyaard L, et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194 (1): 107-12.
        • Xu M, et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275 (23): 17440-6.

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