Lactoferrin/LTF Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LTF (Lactotransferrin, also known as LF; HLF2; GIG12; HEL110), located on 3p21.31, is conserved in chimpanzee, dog, cow, mouse, and rat. The gene produces a 78182 Da protein composed of 710 amino acids. This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. Diseases such as Mastitis and Keratoconjunctivitis Sicca are associated with LTF. The related pathways of LTF include the Response of Mtb to phagocytosis and the Innate Immune System.

Lactoferrin/LTF Protein (2)

    Lactoferrin/LTF Antibody (9)

      Lactoferrin/LTF ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      Lactoferrin/LTF cDNA Clone (26)

      NM_002343.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008522.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      Lactoferrin/LTF Lysate (2)

        Lactoferrin/LTF の背景知識

        Lactotransferrin, also known as Lactoferrin, Talalactoferrin, and LTF, is a secreted protein that belongs to the transferrin family. Transferrins are iron binding transport proteins that can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B, and C have opioid antagonist activity. Lactoferrin A shows a preference for mu-receptors, while lactoferricin B and lactoferricin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Lactoferrin / LTF is a globular glycoprotein that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin / LTF is also present in secondary granules of PMN and is secreted by some acinar cells. Lactoferrin / LTF can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk. Lactoferrin / LTF is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucose. In particular, lactoferrin provides an antibacterial activity to human infants. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.

        Lactoferrin/LTF の参考文献

        • Sánchez L, et al.,1992, Arch. Dis. Child. 67 (5): 657 - 61.
        • Wakabayashi H, et al., 2000, J. Antimicrob. Chemother. 46 (4): 595-602.
        • Nozaki A, et al., 2003, J. Biol. Chem. 278 (12): 10162-73.
        • Azzam HS, et al., 2007, Liver Int. 27 (1): 17-25.

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