L1CAM Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

L1CAM (L1 Cell Adhesion Molecule, also known as S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1), located on Xq28, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 140003 Da protein composed of 1257 amino acids. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. Diseases such as Masa Syndrome and Corpus Callosum, Partial Agenesis Of, X-Linked are associated with L1CAM. The related pathways of L1CAM include Neuroscience and Cell surface interactions at the vascular wall.

L1CAM Protein (1)

    L1CAM Antibody (13)

      L1CAM ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      L1CAM cDNA Clone (27)

      NM_024003.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_000425.4

      In expression vector

      NM_008478.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      L1CAM Lysate (1)

        L1CAM の背景知識

        L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.

        L1CAM の参考文献

        • Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
        • Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
        • Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
        • Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
        • Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
        • Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.

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