kynureninase/KYNU Proteins, Antibodies, cDNA Clones Research Reagents

KYNU (Kynureninase, also known as KYNUU; VCRL2), located on 2q22.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, C.elegans, S.cerevisiae, E.gossypii, and N.crassa. The gene produces a 52352 Da protein composed of 465 amino acids. Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Diseases such as Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2 are associated with KYNU. The related pathways of KYNU include Folate Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline, and tryptophan catabolism.

kynureninase/KYNU Protein (2)

    kynureninase/KYNU Antibody (10)

      kynureninase/KYNU cDNA Clone (30)

      NM_003937.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_027552.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      kynureninase/KYNU Lysate (2)

        kynureninase/KYNU の背景知識

        KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population. The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2.

        kynureninase/KYNU の参考文献

        • Lima S, et al. (2007) Crystal structure of Homo sapiens kynureninase. Biochemistry. 46(10): 2735-44.
        • Momany C, et al. (2004) Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 43(5): 1193-203.
        • Toma S, et al. (1997) Cloning and recombinant expression of rat and human kynureninase. FEBS Lett. 408(1): 5-10.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.