KRT6A/Cytokeratin6A Antibodies, cDNA Clones Research Reagents

KRT6A (Keratin 6A, also known as K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D), located on 12q13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, and chicken. The gene produces a 60045 Da protein composed of 564 amino acids. The protein encoded by this gene is a member of the keratin gene family. Diseases such as Pachyonychia Congenita 3 and Pachyonychia Congenita 1 are associated with KRT6A. The related pathways of KRT6A include Cytoskeleton remodeling Neurofilaments and Ectoderm Differentiation.

KRT6A/Cytokeratin6A Antibody (3)

    KRT6A/Cytokeratin6A cDNA Clone (43)

    BC014152

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_005554.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008476.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    KRT6A/Cytokeratin6A qPCR Primer (1)

    KRT6A/Cytokeratin6A の背景知識

    Mutations in the KRT6A or KRT16 gene cause pachyonychia congenita type 1 (PC-1), while mutations in KRT16 or KRT6C underlie focal palmoplantar keratoderma (FPPK). Pachyonychia congenita (PC) is an autosomal dominant, very rare keratin disorder caused by mutations in any of at least four genes (KRT6A, KRT6B, KRT16, or KRT17), which can lead to hypertrophic nail dystrophy and palmoplantar keratoderma, among other manifestations. A de novo missense mutation in the KRT6A gene, I462S, has been found in a sporadic PC-1 patient. The identification of this novel mutation in the KRT6A gene provides further evidence that mutation in the KRT6A gene causes PC-1 phenotype.

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