KREMEN1 Proteins, Antibodies, cDNA Clones Research Reagents

KREMEN1 (Kringle Containing Transmembrane Protein 1, also known as KRM1; ECTD13; KREMEN), located on 22q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 51744 Da protein composed of 473 amino acids. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. Diseases such as Ectodermal Dysplasia 13, Hair/Tooth Type and Hand, Foot And Mouth Disease are associated with KREMEN1. The related pathways of KREMEN1 include Signaling by GPCR and S45 mutants of beta-catenin.

KREMEN1 Protein (1)

    KREMEN1 Antibody (1)

      KREMEN1 cDNA Clone (13)

      NM_032045.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      KREMEN1 Lysate (1)

        KREMEN1 の背景知識

        KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.

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