KLF5 Antibodies, cDNA Clones Research Reagents

KLF5 (Kruppel Like Factor 5, also known as CKLF; IKLF; BTEB2), located on 13q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Diseases such as Cardiomyopathy, Dilated, 1Ff, and colorectal cancer are associated with KLF5. The related pathways of KLF5 include the Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Glucose / Energy Metabolism.

KLF5 Antibody (1)

    KLF5 cDNA Clone (30)

    NM_001730.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_009769.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    KLF5 の背景知識

    Kruppel-like factor 5 (KLF5) belongs to a family of zinc-finger-containing transcription factors that are involved in regulating the expression of a wide range of genes, thereby affecting diverse cellular functions. The activities of KLF5 are regulated by multiple signaling pathways including Wnt, Ras, TGFbeta, Hippo, Notch, retinoic acid receptor, and hormone receptors. The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context-dependent. Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor growth. Kruppel-like factor (KLF) 5, which initiates vascular smooth muscle cell (VSMC) proliferation, also participates in Angiotensin (Ang) II-induced vascular remodeling. Kruppel-like factor 5 (KLF5) is a key transcriptional regulator that is typically pro-proliferative in non-transformed epithelial cells but inhibits proliferation in transformed epithelial cells.

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