KIR2DL4 Proteins, Antibodies, cDNA Clones Research Reagents

KIR2DL4 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4, also known as G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS), located on 19q13.42, is conserved in chimpanzee, Rhesus monkey, and cow. The gene produces a 41487 Da protein composed of 377 amino acids. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Diseases such as Partial Duplication Of Chromosome 19 and Acute Diarrhea are associated with KIR2DL4. The related pathways of KIR2DL4 include the Immune response Role of DAP12 receptors in NK cells and the Innate Immune System.

KIR2DL4 Protein (2)

    KIR2DL4 Antibody (2)

      KIR2DL4 cDNA Clone (2)

      BC041611

      In expression vector

      In lentiviral vector

      KIR2DL4 qPCR Primer (1)

      KIR2DL4 Lysate (2)

        KIR2DL4 の背景知識

        KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

        KIR2DL4 の参考文献

        • Selvakumar A. et al., 1997, Tissue Antigens. 48 (4 Pt 1): 285-94.
        • Selvakumar A. et al., 1997, Immunol Rev. 155: 183-96.
        • Selvakumar A. et al., 1997, Tissue Antigens. 49 (6): 564-73.

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