Kell/KEL Antibodies, cDNA Clones Research Reagents

KEL (Kell Metallo-Endopeptidase (Kell Blood Group, also known as ECE3; Kell; CD238), located on 7q34, is a Protein Coding gene. The gene produces an 82824 Da protein composed of 732 amino acids. The KEL gene encodes the Kell blood group protein, a metalloendopeptidase that preferentially cleaves big endothelin-3 to produce bioactive endothelin-3. The Kell system, encoded by the KEL gene, is one of the most clinically important blood group systems. Diseases such as Blood Group--Kell System and Choreoacanthocytosis are associated with KEL. The related pathways of KEL include Signaling by GPCR and Peptide ligand-binding receptors.

Kell/KEL Antibody (2)

    Kell/KEL cDNA Clone (26)

    BC003135

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_032540.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    Kell/KEL の背景知識

    KEL (Kell Metallo-Endopeptidase (Kell Blood Group)) is a Protein Coding gene. This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. It presents two major alleles, KEL1(K) and KEL2(k), but a variety of mutations give rise to weakened (K(mod) phenotype) or lack (K0 phenotype) of Kell antigen expression. The Kell system, encoded by the KEL gene, is one of the most clinically important blood group systems. The very rare KEL:5 results from silent KEL genes also called KELnull alleles. In a few cases, the rare KEL:1,-2 phenotype may be associated with silent KEL*02 alleles. Diseases associated with KEL include Blood Group--Kell System and Choreoacanthocytosis.

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