Kallikrein 8 Proteins, Antibodies, cDNA Clones Research Reagents

All Kallikrein 8 reagents are produced in house and quality controlled, including 4 Kallikrein 8 Antibody, 15 Kallikrein 8 Gene, 1 Kallikrein 8 Lysate, 1 Kallikrein 8 Protein, 2 Kallikrein 8 qPCR. All Kallikrein 8 reagents are ready to use.

Kallikrein 8 Protein (1)

    Kallikrein 8 Antibody (4)

      Kallikrein 8 cDNA Clone (15)

      BC040887

      In expression vector

      In lentiviral vector

      NM_008940.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Kallikrein 8 Lysate (1)

        Kallikrein 8 の背景知識

        Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein and KLK8, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily. It is a serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8 / KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.

        Kallikrein 8 の参考文献

        • Yoshida S., et al.,(1998), Sequence analysis and expression of human neuropsin cDNA and gene. Gene 213:9-16.
        • Underwood L.J., et al., (1999), Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.Cancer Res. 59:4435-4439.
        • Mitsui S., et al.,(1999), A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.Eur. J. Biochem. 260:627-634.

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