IZUMO1 Proteins, Antibodies, cDNA Clones Research Reagents

IZUMO1 (Izumo Sperm-Egg Fusion 1, also known as OBF; IZUMO), located on 19q13.33, is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat. The gene produces a 38930 Da protein composed of 350 amino acids. The human gene encodes a type I membrane protein of the Ig superfamily containing an extracellular Ig domain with a putative glycosylation site. IZUMO1 is essential for sperm-egg plasma membrane binding and fusion. Diseases such as Glaucoma, Normal Tension are associated with IZUMO1. The related pathways of IZUMO1 include Fertilization.

IZUMO1 Protein (1)

    IZUMO1 Antibody (2)

      IZUMO1 cDNA Clone (14)

      BC034769

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001321864.1

      In expression vector

      IZUMO1 qPCR Primer (1)

      IZUMO1 Lysate (1)

        IZUMO1 の背景知識

        Izumo is a sperm membrane protein that plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain the Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain, or both of Izumo 1 are required for the formation of multimers of a higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes, and Izumo 3 and 4 forming a single larger complex. Izumo1 is essential for sperm-egg plasma membrane binding and fusion.

        IZUMO1 の参考文献

        • Inoue N, et al. (2008) Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun. 377(3):910-4.
        • Ikram MK, et al. (2010) Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 6(10):e1001184.
        • Sklar P, et al. (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 43(10):977-83.

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