IRAK4 Proteins, Antibodies, cDNA Clones Research Reagents

IRAK4 (Interleukin 1 Receptor Associated Kinase 4, also known as IPD1; IMD67; REN64; IRAK-4; NY-REN-64), located on 12q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, rice, and frog. The gene produces a 51530 Da protein composed of 460 amino acids. This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. Diseases such as Irak4 Deficiency and Invasive Pneumococcal Disease, Recurrent Isolated are associated with IRAK4. The related pathways of IRAK4 include Bacterial infections in CF airways and NF-KappaB Family Pathway.

IRAK4 Protein (1)

    IRAK4 Antibody (2)

      IRAK4 cDNA Clone (30)

      NM_016123.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_029926.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      IRAK4 qPCR Primer (1)

      IRAK4 Lysate (1)

        IRAK4 の背景知識

        Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for the induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defense while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.

        IRAK4 の参考文献

        • Strelow,A. et al., 2003, FEBS Lett. 547 (1-3):157-61.
        • Kim,T.W. et al., 2007, J Exp Med. 204 (5):1025-36.
        • Trumstedt,C. et al., 2007, J Leukoc Biol. 81 (6):1591-8.
        • Li,X. et al., 2008, Eur J Immunol. 38 (3):614-8.
        • Staschke,K.A. et al., 2009, J Immunol. 183 (1): 568-77. 

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