Insulin Proteins, Antibodies, cDNA Clones Research Reagents

INS (Insulin, also known as IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10), located on 11p15.5, is conserved in chimpanzee, dog, mouse, rat, chicken, zebrafish, and frog. The gene produces a 11981 Da protein composed of 110 amino acids. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. Diseases such as Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10 are associated with INS. The related pathways of INS include RET signaling and Folate Metabolism.

Insulin Protein (1)

    Insulin Antibody (5)

      Insulin cDNA Clone (13)

      NM_000207.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Insulin qPCR Primer (1)

      Insulin の背景知識

      INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.

      Insulin の参考文献

      • Veedfald S, Plamboeck A, Deacon C F, et al. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016, 310(1): G43-G51.

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