ING4 Proteins, cDNA Clones Research Reagents

ING4 (Inhibitor Of Growth Family Member 4, also known as my036; p29ING4), located on 12p13.31, is a Protein Coding gene. The gene produces a 28530 Da protein composed of 249 amino acids. ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 directly interacted with HPH2 (EGLN1), a mediator of HIF stability, providing a mechanism for ING4 recruitment to HIF. The protein contains a C-terminal plant homeodomain finger motif and 2 nuclear localization signals. The related pathways of ING4 include Chromatin organization.

ING4 Protein (1)

    ING4 cDNA Clone (15)

    BC007781

    クローニングベクター cDNA 製品

    In lentiviral vector

    ING4 qPCR Primer (1)

    ING4 の背景知識

    ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP3/p3, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation, it may function in DNA replication. ING4 may also inhibit tumor progression by modulating the transcriptional output of signaling pathways that regulate cell proliferation.

    ING4 の参考文献

    • Shiseki M. et al., 2003, Cancer Res. 63 (10): 2373-8.
    • Garkavtsev. et al., 2004, Nature. 428 (6980): 328-32.
    • Tsai. et al., 2008, Exp Cell Res. 314 (17): 3130-41.

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