IL5RA Proteins, Antibodies, cDNA Clones Research Reagents

IL5RA (Interleukin 5 Receptor Subunit Alpha, also known as IL5R; CD125; CDw125; HSIL5R3), located on 3p26.2, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. The gene produces a 47685 Da protein composed of 420 amino acids. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. Diseases such as Disseminated Eosinophilic Collagen Disease and Hypereosinophilic Syndrome are associated with IL5RA. The related pathways of IL5RA include RET signaling and Signaling by GPCR.

IL5RA Protein (2)

    IL5RA Antibody (3)

      IL5RA cDNA Clone (28)

      NM_000564.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_175724.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008370.2

      In expression vector

      In lentiviral vector

      IL5RA qPCR Primer (1)

      IL5RA Lysate (2)

        IL5RA の背景知識

        Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand-specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony-stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine that is particularly important in the development of asthma for the terminal differentiation, activation, and survival of committed eosinophil precursors.

        IL5RA の参考文献

        • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.
        • Cheong HS, et al. (2005) Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. J Hum Genet. 50(12): 628-34.
        • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.

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