IL4R Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL4R (Interleukin 4 Receptor, also known as CD124; IL4RA; IL-4RA), located on 16p12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces an 89658 Da protein composed of 825 amino acids. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. Diseases such as Ige Responsiveness, Atopic, and Human Immunodeficiency Virus Type 1 are associated with IL4R. The related pathways of IL4R include AKT Signaling Pathway and Development IGF-1 receptor signaling.

IL4R Protein (9)

    IL4R Antibody (17)

      IL4R ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      IL4R cDNA Clone (17)

      NM_000418.3

      In expression vector

      In lentiviral vector

      NM_133380.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      CM001295.1

      In expression vector

      IL4R qPCR Primer (2)

      IL4R Lysate (8)

        IL4R の背景知識

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD124, also known as the interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to a soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.

        IL4R の参考文献

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

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