IL21 Receptor Proteins, Antibodies, cDNA Clones Research Reagents

IL21R (Interleukin 21 Receptor, also known as NILR; CD360; IMD56), located on 16p12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 59130 Da protein composed of 538 amino acids. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). Diseases such as Immunodeficiency 56 and Ige Responsiveness, Atopic are associated with IL21R. The related pathways of IL21R include Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AKT Signaling Pathway.

IL21 Receptor Protein (8)

IL21 Receptor Antibody (10)

    IL21 Receptor cDNA Clone (14)

    AF477986.1

    クローニングベクター cDNA 製品

    NM_001012469.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    IL21 Receptor Lysate (8)

      IL21 Receptor の背景知識

      Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and/or activation. The IL-21R is widely distributed on lymphohematopoietic cells and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterized by the overproduction of pathogenic autoantibodies.

      IL21 Receptor の参考文献

      • Asao H, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 167(1): 1-5.
      • Wu Z, et al. (2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
      • De Totero D, et al. (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 107(9): 3708-15.
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