IL1RA Proteins, Antibodies, cDNA Clones Research Reagents

IL1RN (Interleukin 1 Receptor Antagonist, also known as DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA), located on 2q14.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 20055 Da protein composed of 177 amino acids. The protein encoded by this gene is a member of the interleukin 1 cytokine family. Diseases such as Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis and Microvascular Complications Of Diabetes 4 are associated with IL1RN. The related pathways of IL1RN include PEDF Induced Signaling and Prolactin Signaling Pathway.

IL1RA Protein (5)

    IL1RA Antibody (7)

      IL1RA cDNA Clone (65)

      NM_173842.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC009745

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001039701.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_022194.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_004826210.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      IL1RA Lysate (2)

        IL1RA の背景知識

        Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein-encoding gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.

        IL1RA の参考文献

        • Langdahl BL, et al. (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner. 15 (3): 402-14.
        • El-Omar EM, et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 404 (6776): 398-402.
        • Steinkasserer A, et al. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13 (3): 654-7.

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