IL18R1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All IL18R1 reagents are produced in house and quality controlled, including 18 IL18R1 Antibody, 4 IL18R1 ELISA, 49 IL18R1 Gene, 11 IL18R1 Lysate, 12 IL18R1 Protein, 3 IL18R1 qPCR. All IL18R1 reagents are ready to use.

IL18R1 Protein (12)

IL18R1 Antibody (18)

    IL18R1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(4)

    IL18R1 cDNA Clone (49)

    NM_003855.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008365.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001106905.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_005625993.1

    In lentiviral vector

    IL18R1 Lysate (11)

      IL18R1 の背景知識

      Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

      IL18R1 の参考文献

      • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
      • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
      • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.

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