IL-9 Proteins, Antibodies, cDNA Clones Research Reagents

IL9 (Interleukin 9, also known as P40; HP40; IL-9), located on 5q31.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 15909 Da protein composed of 144 amino acids. The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. Diseases such as Severe Combined Immunodeficiency, X-Linked, and Asthma are associated with IL9. The related pathways of IL9 include Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and NF-KappaB Family Pathway.

IL-9 Protein (3)

    IL-9 Antibody (8)

      IL-9 cDNA Clone (28)

      BC066285

      In expression vector

      In lentiviral vector

      NM_008373.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001105747.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      IL-9 Lysate (3)

        IL-9 の背景知識

        Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects the differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells synergizes with TGF-β1 to differentiate naive CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and the absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight the role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses.

        IL-9 の参考文献

        • Elyaman W, et al. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 106(31): 12885-90.
        • Dong Q, et al. (1999) IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol. 29(7): 2130-9.
        • Kimura Y, et al. (1995) Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 7(1): 115-20.

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