IL-6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL6 (Interleukin 6, also known as CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2), located on 7p15.3, is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken. The gene produces a 23718 Da protein composed of 212 amino acids. IL6 is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL6 has been defined as an essential role in directing the transition from innate to acquired immunity.

IL-6 Protein (6)

IL-6 Antibody (26)

    IL-6 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

    IL-6 cDNA Clone (66)

    NM_000600.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031168.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_012589.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001042733.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001003301.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    IL-6 の背景知識

    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.

    IL-6 の参考文献

    • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
    • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
    • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

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