IL-20 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL20 (Interleukin 20, also known as IL-20; IL10D; ZCYTO10), located on 1q32.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 20072 Da protein composed of 176 amino acids. The protein encoded by this gene is a cytokine structurally related to IL10. The IL20 protein contains 6 conserved cysteine residues and shares 76% amino acid identity with its murine counterpart. Diseases such as Psoriasis are associated with IL20. The related pathways of IL20 include PEDF Induced Signaling and Akt Signaling.

IL-20 Protein (2)

    IL-20 Antibody (7)

      IL-20 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      IL-20 cDNA Clone (28)

      BC069311

      In expression vector

      In lentiviral vector

      NP_067355.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001143881.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      IL-20 の背景知識

      IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. It has been shown that interleukin-20 transduces its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates the proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. Also, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

      IL-20 の参考文献

      • Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
      • Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
      • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.

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