IL-13 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL13 (Interleukin 13, also known as P600; IL-13), located on 5q31.1, is a Protein Coding gene. The gene produces a 15816 Da protein composed of 146 amino acids. IL13 is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and diseases. IL-13 protein and antibody are more importantly implicated as a central mediator of immunoregulatory processes in various cell types. Diseases such as Asthma and Allergic Rhinitis are associated with IL13.

IL-13 Protein (5)

    IL-13 Antibody (10)

      IL-13 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      IL-13 cDNA Clone (39)

      NM_002188.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008355.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_053828.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      IL-13 Lysate (5)

        IL-13 の背景知識

        Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and diseases. Also, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody are more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

        IL-13 の参考文献

        • Junttila IS, et al. (2008) Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 205(11): 2595-608.
        • Shimamura T,et al. (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 181(7): 4656-65.

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