IL-1 R9 Proteins, Antibodies, cDNA Clones Research Reagents

IL1RAPL2 (Interleukin 1 Receptor Accessory Protein Like 2, also known as IL1R9; IL-1R9; TIGIRR-1; IL1RAPL-2), located on Xq22.3, is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 78670 Da protein composed of 686 amino acids. The protein encoded by this gene is a member of the interleukin 1 receptor family. Along with IL1RAPL1, IL1RAPL2 forms a distinct subset of orphan receptors in the IL1R superfamily. Diseases such as Cinca Syndrome and Muckle-Wells Syndrome are associated with IL1RAPL2.

IL-1 R9 Protein (2)

    IL-1 R9 Antibody (2)

      IL-1 R9 cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      IL-1 R9 qPCR Primer (1)

      IL-1 R9 Lysate (2)

        IL-1 R9 の背景知識

        X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in the fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptors are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.

        IL-1 R9 の参考文献

        • Jin H, et al. (2000) Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation. Eur J Hum Genet. 8(2): 87-94.
        • Sana TR, et al. (2000) Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. Genomics. 69(2): 252-62.
        • Gambino F, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104(21): 9063-8.

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