IgJ Proteins, Antibodies, cDNA Clones Research Reagents

JCHAIN (Joining Chain Of Multimeric IgA And IgM, also known as IGJ; JCH; IGCJ), located on 4q13.3, is a Protein Coding gene. The gene produces a 18099 Da protein composed of 159 amino acids. JCHAIN is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. Diseases such as Alpha Chain Disease and Climatic Droplet Keratopathy are associated with JCHAIN. The related pathways of JCHAIN include Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.

IgJ Protein (1)

    IgJ Antibody (2)

      IgJ cDNA Clone (13)

      NM_144646.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      IgJ の背景知識

      Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA, it induces larger polymers. Immunoglobulin J chain / IGJ also helps to bind these immunoglobulins to the secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.

      IgJ の参考文献

      • Zikan, J. et al., 1985, Proc Natl Acad Sci USA. 82 (17): 5905-9.
      • Koshland, M.E. et al., 1985, Annu Rev Immunol. 3: 425-53.
      • Iwase,T. et al., 1993, Cell Struct Funct. 18 (5): 297-302.
      • Johansen, F.E. et al., 2000, Scand J Immunol. 52 (3): 240-8.
      • Lim, J.H. et al., 2006, J Immunol. 177 (8): 5420-9. 

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.