IGFBP-6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IGFBP6 (Insulin-Like Growth Factor Binding Protein 6, also known as IBP6), located on 12q13.13, is a Protein Coding gene. The gene produces a 25322 Da protein composed of 240 amino acids. IGFBP6 binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. Diseases such as Acth-Secreting Pituitary Adenoma and Insulin-Like Growth Factor I are associated with IGFBP6.

IGFBP-6 Protein (3)

    IGFBP-6 Antibody (10)

      IGFBP-6 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      IGFBP-6 cDNA Clone (27)

      NM_002178.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008344.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC099742.1

      クローニングベクター cDNA 製品

      IGFBP-6 Lysate (3)

        IGFBP-6 の背景知識

        Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.

        IGFBP-6 の参考文献

        • Denys H, et al. (2004) Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. Oncogene. 23(3): 654-64.
        • Bach LA. Insulin-like growth factor binding protein-6: the "forgotten" binding protein? Horm Metab Res. 31(2-3): 226-34.
        • Bach LA. IGFBP-6 five years on; not so 'forgotten'? Growth Horm IGF Res. 15(3): 185-92.

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